RIBOSOME BIOGENESIS DISRUPTION MEDIATED CHROMATIN STRUCTURE CHANGES REVEALED BY SRATAC, A CUSTOMIZABLE END TO END ANALYSIS PIPELINE FOR ATAC-SEQ

Ribosome biogenesis disruption mediated chromatin structure changes revealed by SRAtac, a customizable end to end analysis pipeline for ATAC-seq

Abstract The nucleolus is a large nuclear body that serves as the primary site for ribosome biogenesis.Recent studies have suggested that it also plays an important role in organizing chromatin architecture.However, to establish a causal relationship between nucleolar ribosome assembly and chromatin architecture, genetic tools are required to disru

read more

Feasibility and Safety of Perioperative Chemotherapy With Fluorouracil Plus Leucovorin, Oxaliplatin, and Docetaxel for Locally Advanced Gastric Cancer Patients in China

BackgroundNeoadjuvant fluorouracil plus leucovorin, oxaliplatin, and docetaxel (FLOT) has shown significant benefits for gastric cancer patients.However, it has not been well accepted in Asian countries.We conducted a prospective study on the safety and feasibility of the FLOT regimen in Chinese patients.MethodsPatients with adenocarcinoma of the s

read more


Economic effectiveness of fixed-dose combination of alogliptin and pioglitazone in diabetes mellitus treatment

Objective: to comparatively assess the weighted average costs associated with the use of alogliptin-pioglitazone combination versus glucagon-like peptide-1 receptor agonists (GLP-1 RAs).Material and methods.A retrospective study involved pharmacoeconomic analysis, including cost-minimization analysis and budget impact analysis, with consideration t

read more